PRP vs. PRF in Aesthetic Medicine

PRP (Platelet-Rich Plasma) and PRF (Platelet-Rich Fibrin) treatment are widely used in the field of regenerative medicine and are derived from our own blood products.  These rejuvenating treatments are used in various aesthetic procedures to promote collagen stimulation and to treat unwanted hair loss, volume loss and pigmentation of the under eyes, and textural concerns.  Below we’ll discuss the key differences in these natural yet effective treatments.

PRP (Platelet-Rich Plasma):

  • Contains a high concentration of platelets suspended in plasma. It’s usually prepared by spinning blood in a centrifuge to separate the components.
  • The desired growth factors are readily available within plasma, but it lacks the fibrin matrix.
  • Commonly used for hair restoration and skin rejuvenation with microneedling.
  • PRP is prepared using an anticoagulant to prevent the blood from clotting during injections.

PRF (Platelet-Rich Fibrin):

  • Also contains concentrated platelets but in a fibrin matrix that forms after the blood is spun. This matrix assists in sustained release of growth factors.
  • It has a more natural and stable structure, promoting a longer duration of action for healing and regeneration.
  • Often used for facial rejuvenation and tissue regeneration.
  • No anticoagulant used in PRF preparation.

Which is Better for Collagen Stimulation?

PRF is often considered better for collagen stimulation due to its sustained release of growth factors, which supports tissue regeneration over a longer period. This can lead to enhanced collagen production and improved skin texture.

What is the Recommended Treatment for Dark Under-Eyes or Under-Eye Hollowing?

Our favorite treatment at Pur Skin Clinic is PRF EZ Gel for a variety of reasons.

  1. Natural Volume Restoration: PRF EZ Gel is derived from your own blood, making it biocompatible and reducing the risk of reactions. It helps restore volume in the under-eye area for a more youthful appearance in a completely natural fashion.
  2. Collagen Stimulation: The growth factors in PRF stimulate collagen production; improving skin texture and elasticity over time, which can help diminish the appearance of hollowness and fine lines.
  3. Improved Skin Quality: PRF can enhance overall skin quality  by promoting healing and addressing issues like discoloration or thinning skin in the under-eye area.
  4. Long-Lasting Results: PRF creates a fibrin matrix that allows for a gradual release of growth factors, leading to more sustained results compared to fillers.
  5. Minimal Downtime: While there will be some expected swelling and bruising, the procedure typically involves minimal recovery time. Most patients are able to resume normal activities 2-5 days after treatment.

Overall, PRF EZ Gel can be an effective option for those looking to improve under-eye volume loss, unwanted pigmentation, and elasticity, while promoting long-term skin health and youthfulness.